International Sports Sciences Association (ISSA) Trainer Practice Exam 2026 - Free Trainer Practice Questions and Study Guide

The statement that training using roughly 6 to 12 repetitions is most effective for achieving muscular hypertrophy is accurate. This range is often recommended in strength training literature because it strikes a balance between the amount of weight lifted (which stimulates muscle fibers) and the volume of training needed to induce muscle growth.

Training within this repetition range typically allows for a moderate to high level of intensity, which is important for creating the mechanical tension necessary for hypertrophy. It also provides enough volume to create metabolic stress, which plays a critical role in activating pathways associated with muscle growth.

This hypertrophy-friendly rep range has been supported by various studies and is widely accepted in fitness and bodybuilding communities. While individual responses to training can vary based on factors like genetics, training experience, and overall program design, the 6 to 12 repetition range serves as a solid guideline for many individuals aiming for muscular size gains.